SCHEMBL1960124

SCHEMBL1960124

Cc1ccc(C(C)(C)c2ccc(N3C(=O)c4ccc(C(c5ccc6c(c5)C(=O)N(C)C6=O)(C(F)(F)F)C(F)(F)F)cc4C3=O)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.47
HSD17B10 Q99714 2/20 0.47
NPC1 O15118 1/20 0.47
TSHR P16473 1/20 0.47
CASP1 P29466 1/20 0.47
RAB9A P51151 1/20 0.47
CASP7 P55210 1/20 0.47
CA9 Q16790 6/20 0.46
CA12 O43570 4/20 0.46
CA1 P00915 4/20 0.46
CA2 P00918 2/20 0.45
POLB P06746 1/20 0.41
HPGD P15428 1/20 0.41
APP P05067 1/20 0.41
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
MAPT P10636 1/20 0.39
ALOX15 P16050 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ESR1 P03372 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19628661 1.00 ALDH1A1 (0.47) ALDH1A1HSD17B10NPC1TSHRCASP1
SCHEMBL12260131 0.95 ALDH1A1 (0.51) ALDH1A1HSD17B10NPC1TSHRCASP1
SCHEMBL1960350 0.94 ALDH1A1 (0.50) ALDH1A1HSD17B10NPC1TSHRCASP1
SCHEMBL12009338 0.93 MEN1 (0.44) ALDH1A1HSD17B10NPC1TSHRCASP1
SCHEMBL16234051 0.89 ALDH1A1 (0.46) ALDH1A1HSD17B10NPC1TSHRCASP1
SCHEMBL30829232 0.88 MEN1 (0.47) ALDH1A1HSD17B10NPC1TSHRCASP1
SCHEMBL1962793 0.88 MEN1 (0.47) ALDH1A1HSD17B10NPC1TSHRCASP1
SCHEMBL15831666 0.88 ALDH1A1 (0.45) ALDH1A1HSD17B10NPC1TSHRCASP1
SCHEMBL25969156 0.88 MEN1 (0.48) ALDH1A1HSD17B10NPC1TSHRCASP1
SCHEMBL1104522 0.87 MEN1 (0.46) ALDH1A1HSD17B10NPC1TSHRCASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3368285-B1 METHOD OF MAKING OPTICAL ARTICLES HAVING GRADIENT LIGHT INFLUENCING PROPERTIES TRANSITIONS OPTICAL INC (US) 2026-04-15 EP disclosed
EP-3368927-B1 OPTICAL ARTICLE WITH GRADIENT LIGHT INFLUENCING PROPERTIES AND METHOD OF MAKING THE SAME TRANSITIONS OPTICAL INC (US) 2024-10-16 EP disclosed
US-12076951-B2 Method of making optical articles having gradient light influencing properties TRANSITIONS OPTICAL, INC. (US) 2024-09-03 US disclosed
US-12055741-B2 Optical articles and method of preparing the same TRANSITIONS OPTICAL, INC. (US) 2024-08-06 US disclosed
EP-3368926-B1 A METHOD OF MAKING AN OPTICAL ARTICLE WITH AN INKJET PRINTING DEVICE TRANSITIONS OPTICAL LTD (IE) 2024-03-06 EP disclosed
US-11714220-B2 Optical article with gradient light influencing properties and method of making the same TRANSITIONS OPTICAL, INC. (US) 2023-08-01 US disclosed
US-20220171110-A1 Optical Articles and Method of Preparing the Same TRANSITIONS OPTICAL, INC. 2022-06-02 US disclosed
US-20220066081-A1 Optical Article with Gradient Light Influencing Properties and Method of Making the Same TRANSITIONS OPTICAL, INC. 2022-03-03 US disclosed
US-11256014-B2 Optical articles and method of preparing the same TRANSITIONS OPTICAL, INC. (US) 2022-02-22 US disclosed
US-11199653-B2 Optical article with gradient light influencing properties and method of making the same TRANSITIONS OPTICAL, INC. (US) 2021-12-14 US disclosed
US-20180299702-A1 Method of Making an Optical Article with an Inkjet Printing Device TRANSITIONS OPTICAL, LTD. (IE) 2018-10-18 US disclosed
US-20180290408-A1 Method of Making Optical Articles Having Gradient Light Influencing Properties TRANSITIONS OPTICAL, INC. 2018-10-11 US disclosed
EP-3368285-A1 METHOD OF MAKING OPTICAL ARTICLES HAVING GRADIENT LIGHT INFLUENCING PROPERTIES Transitions Optical, Inc. (US) 2018-09-05 EP disclosed
EP-3368927-A1 OPTICAL ARTICLE WITH GRADIENT LIGHT INFLUENCING PROPERTIES AND METHOD OF MAKING THE SAME Transitions Optical, Inc. (US) 2018-09-05 EP disclosed
EP-3368925-A1 OPTICAL ARTICLES AND METHOD OF PREPARING THE SAME Transitions Optical, Inc. (US) 2018-09-05 EP disclosed
EP-3368926-A1 A METHOD OF MAKING AN OPTICAL ARTICLE WITH AN INKJET PRINTING DEVICE Transitions Optical, Ltd. (IE) 2018-09-05 EP disclosed
US-20170037173-A1 Photoalignment Materials Having Improved Adhesion TRANSITIONS OPTICAL, INC. 2017-02-09 US disclosed
US-9475901-B2 Photoalignment materials having improved adhesion TRANSITIONS OPTICAL, INC. (US) 2016-10-25 US disclosed
EP-2510023-B1 PHOTOALIGNMENT MATERIALS HAVING IMPROVED ADHESION TRANSITIONS OPTICAL INC (US) 2013-09-11 EP disclosed
US-20110135850-A1 PHOTOALIGNMENT MATERIALS HAVING IMPROVED ADHESION TRANSITIONS OPTICAL, INC. (US) 2011-06-09 US disclosed