Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19604095 | 0.89 | LOXL2 (0.39) | TAAR1LOXL2KDM4EALDH1A1MAPT | |
| SCHEMBL10222551 | 0.84 | CYP1A2 (0.45) | LOXL2MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL22932538 | 0.83 | LOXL2 (0.37) | LOXL2MEN1KMT2ANPC1MAPT | |
| SCHEMBL18551227 | 0.82 | MAPT (0.41) | TAAR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL16901843 | 0.79 | HDAC6 (0.51) | LOXL2MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL10670572 | 0.76 | LOXL2 (0.42) | TAAR1LOXL2MEN1KMT2AKDM4E | |
| SCHEMBL18067931 | 0.76 | CA12 (0.39) | LOXL2MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL14756189 | 0.76 | LOXL2 (0.42) | TAAR1LOXL2MEN1KMT2AKDM4E | |
| SCHEMBL10674648 | 0.76 | LOXL2 (0.42) | TAAR1LOXL2MAPTCYP1A2CA12 | |
| SCHEMBL14756356 | 0.76 | LOXL2 (0.42) | LOXL2CA12CA1CA2CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas Operations, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |
| WO-2017197036-A1 | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2017-11-16 | — | — | WO | disclosed |