Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | COMT | P21964 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18926693 | 0.84 | PIK3CD (0.67) | PIK3CDNPC1RAB9AL3MBTL1P2RX7 | |
| SCHEMBL21698479 | 0.81 | ALOX15 (0.43) | PIK3CDNPC1RAB9AALOX15P2RX7 | |
| SCHEMBL2619229 | 0.77 | PIK3CD (0.55) | PIK3CDNPC1RAB9AL3MBTL1P2RX7 | |
| SCHEMBL24664423 | 0.75 | PIK3CD (0.47) | PIK3CDNPC1RAB9AL3MBTL1P2RX7 | |
| SCHEMBL18226610 | 0.74 | PIK3CD (0.58) | PIK3CDALOX15P2RX7 | |
| SCHEMBL23875186 | 0.74 | ALOX15 (0.38) | PIK3CDNPC1RAB9AL3MBTL1ALOX15 | |
| SCHEMBL30875935 | 0.73 | ITGB3 (0.43) | ALOX15POLBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2624402 | 0.72 | PRMT5 (0.59) | NPC1RAB9AL3MBTL1P2RX7POLB | |
| SCHEMBL1308167 | 0.72 | ALOX15 (0.62) | PIK3CDALOX15 | |
| SCHEMBL22387991 | 0.72 | PIK3CD (0.53) | PIK3CDNPC1RAB9AL3MBTL1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017197036-A1 | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2017-11-16 | — | — | WO | disclosed |