SCHEMBL19604155

SCHEMBL19604155

CCc1cccc(N2CCC2)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 1/20 0.60
AGXT P21549 3/20 0.57
ALOX5 P09917 1/20 0.53
MGLL Q99685 1/20 0.51
L3MBTL3 Q96JM7 2/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
MBTD1 Q05BQ5 1/20 0.45
TP53BP1 Q12888 1/20 0.45
KDM4E B2RXH2 3/20 0.44
ALDH1A1 P00352 3/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CHKA P35790 2/20 0.44
MEN1 O00255 2/20 0.43
HPGD P15428 2/20 0.43
KMT2A Q03164 2/20 0.43
GAA P10253 1/20 0.43
HSD17B10 Q99714 1/20 0.43
USP2 O75604 1/20 0.43
POLB P06746 1/20 0.43
MAPT P10636 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL166575 0.96 PRMT6 (0.65) PRMT6AGXTALOX5MGLLL3MBTL3
SCHEMBL4480384 0.94 PRMT6 (0.68) PRMT6AGXTALOX5MGLLL3MBTL3
SCHEMBL8189615 0.85 AGXT (0.67) PRMT6AGXTALOX5MGLLKDM4E
SCHEMBL19601451 0.85 PRMT6 (0.57) PRMT6AGXTL3MBTL3L3MBTL1MBTD1
SCHEMBL14376187 0.84 PRMT6 (0.47) PRMT6AGXTALOX5MGLLL3MBTL3
SCHEMBL301359 0.84 ADRB1 (0.62) ALDH1A1MAPTDRD2DRD3
SCHEMBL7508176 0.84 PRMT6 (0.47) PRMT6AGXTALOX5MGLLL3MBTL3
SCHEMBL4507051 0.84 AGXT (0.65) PRMT6AGXTALOX5MGLLL3MBTL1
Hydrochloric Acid SCHEMBL11552421 0.82 ADRB1 (0.60) ALDH1A1MAPTDRD2DRD3
Hydrochloric Acid SCHEMBL9742661 0.82 ADRB1 (0.60) ALDH1A1MAPTDRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017197046-A1 C3-CARBON LINKED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION C4 THERAPEUTICS, INC. (US) 2017-11-16 WO disclosed
WO-2017197051-A1 AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION C4 THERAPEUTICS, INC. (US) 2017-11-16 WO disclosed
WO-2017197055-A1 HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION C4 THERAPEUTICS, INC. (US) 2017-11-16 WO disclosed
WO-2017197056-A1 BROMODOMAIN TARGETING DEGRONIMERS FOR TARGET PROTEIN DEGRADATION C4 THERAPEUTICS, INC. (US) 2017-11-16 WO disclosed