Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | GRK2 | P25098 | 1/20 | 0.48 |
| ▸ | GRK5 | P34947 | 1/20 | 0.48 |
| ▸ | GRK3 | P35626 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17131918 | 0.86 | KDM4E (0.50) | HTTSMN1; SMN2HPGDMAPTLMNA | |
| SCHEMBL21021028 | 0.82 | TSHR (0.56) | HTTSMN1; SMN2HPGDMAPTLMNA | |
| SCHEMBL17131975 | 0.78 | HTT (0.53) | HTTSMN1; SMN2HPGDMAPTLMNA | |
| SCHEMBL14970814 | 0.74 | SMN1; SMN2 (0.71) | SMN1; SMN2HPGDMAPTLMNAATM | |
| SCHEMBL1360195 | 0.71 | HDAC8 (0.65) | SMN1; SMN2HPGDLMNAPOLBATM | |
| SCHEMBL29936927 | 0.70 | CA1 (0.66) | SMN1; SMN2HPGDMAPTLMNAPOLB | |
| SCHEMBL842634 | 0.69 | SMN1; SMN2 (0.81) | HTTSMN1; SMN2HPGDMAPTTSHR | |
| SCHEMBL10084687 | 0.69 | NPC1 (0.73) | HTTSMN1; SMN2HPGDLMNAPOLB | |
| SCHEMBL11626709 | 0.69 | GAA (0.76) | HTTSMN1; SMN2HPGDMAPTLMNA | |
| SCHEMBL1753828 | 0.69 | L3MBTL1 (0.71) | SMN1; SMN2MAPTLMNAPOLBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190151289-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) Histone Demethylase | UNIV YALE (US) | 2019-05-23 | — | — | US | disclosed |
| US-20190151289-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) Histone Demethylase | UNIV YALE (US) | 2019-05-23 | — | — | US | disclosed |
| WO-2017197210-A1 | IDENTIFICATION OF SMALL MOLECULE INHIBITORS OF JUMONJI AT-RICH INTERACTIVE DOMAIN 1A (JARID1A) HISTONE DEMETHYLASE | YALE UNIVERSITY (US) | 2017-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151289-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) Histone Demethylase | KDM1A, KDM1B, JMJD1C | HTT 3714/4885SMN1; SMN2 4161/4885HPGD 2548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.