Sugi Predict

Sugi Predict / Compounds / SCHEMBL1960741

SCHEMBL1960741

SCHEMBL1960741

COC(=O)c1ccc(-c2nn(-c3ccccc3)cc2Sc2ccc(Cl)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FAAH O00519 3/20 0.56
▸ ALDH1A1 P00352 5/20 0.55
▸ MAPT P10636 5/20 0.55
▸ KMT2A Q03164 4/20 0.55
▸ KDM4E B2RXH2 4/20 0.55
▸ MEN1 O00255 3/20 0.55
▸ HPGD P15428 3/20 0.55
▸ POLB P06746 1/20 0.55
▸ HSP90AA1 P07900 1/20 0.55
▸ TDP1 Q9NUW8 1/20 0.55
▸ KCNH2 Q12809 2/20 0.53
▸ L3MBTL1 Q9Y468 2/20 0.53
▸ MAPK1 P28482 1/20 0.53
▸ LMNA P02545 2/20 0.52
▸ AURKA O14965 6/20 0.51
▸ NPSR1 Q6W5P4 1/20 0.50
▸ DRD2 P14416 1/20 0.49
▸ CA12 O43570 1/20 0.48
▸ CA1 P00915 1/20 0.48
▸ CA2 P00918 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1535178 0.88 FAAH (0.59) FAAHALDH1A1MAPTKMT2AKDM4E
SCHEMBL1962085 0.88 MEN1 (0.61) FAAHALDH1A1MAPTKMT2AKDM4E
SCHEMBL1535388 0.87 FAAH (0.50) FAAHALDH1A1MAPTKMT2AKDM4E
SCHEMBL1535172 0.87 MAPT (0.50) FAAHALDH1A1MAPTKMT2AKDM4E
SCHEMBL1962921 0.87 MAPK1 (0.52) FAAHALDH1A1MAPTKMT2AKDM4E
SCHEMBL1535304 0.85 FAAH (0.56) FAAHALDH1A1MAPTKMT2AKDM4E
SCHEMBL1961190 0.85 MAPT (0.57) FAAHALDH1A1MAPTKMT2AKDM4E
SCHEMBL1964814 0.85 MAPT (0.54) FAAHALDH1A1MAPTKMT2AKDM4E
SCHEMBL1963570 0.82 MAPT (0.53) FAAHALDH1A1MAPTKMT2AKDM4E
SCHEMBL1535253 0.82 MAPT (0.53) FAAHALDH1A1MAPTKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2299824-B1 PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH MERCK SHARP & DOHME (US) 2013-06-19 — — EP claimed
US-20110144056-A1 PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH MERCK SHARP & DOHME CORP. 2011-06-16 — — US claimed
EP-2299824-B1 PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH MERCK SHARP & DOHME (US) 2013-06-19 — — EP disclosed
EP-2299824-B1 PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH MERCK SHARP & DOHME (US) 2013-06-19 — — EP disclosed
US-20110144056-A1 PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH MERCK SHARP & DOHME CORP. 2011-06-16 — — US disclosed
US-20110144056-A1 PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH MERCK SHARP & DOHME CORP. 2011-06-16 — — US disclosed
US-20110144056-A1 PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH MERCK SHARP & DOHME CORP. 2011-06-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110144056-A1 PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH FAAH, FAAH2, HRH2 FAAH 1/4885ALDH1A1 1185/4885MAPT 878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.