Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | USP14 | P54578 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1260945 | 0.86 | SCN9A (0.65) | SCN9ASCN5AALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL899454 | 0.85 | SCN9A (0.64) | SCN9ASCN5AALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL27861253 | 0.85 | SCN9A (0.48) | SCN9ASCN5AALDH1A1 | |
| SCHEMBL4830054 | 0.81 | SCN9A (0.49) | SCN9ASCN5AALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL14435340 | 0.79 | SCN9A (0.45) | SCN9ASCN5AALDH1A1NPSR1HPGD | |
| SCHEMBL13577960 | 0.78 | SCN9A (0.46) | SCN9ASCN5AALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL4822336 | 0.78 | CNR2 (0.47) | SCN9ASCN5AALDH1A1NPSR1HPGD | |
| SCHEMBL4565896 | 0.77 | SCN9A (0.43) | SCN9ASCN5AALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL4827022 | 0.77 | SCN9A (0.46) | SCN9ASCN5AALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL772052 | 0.75 | HRH2 (0.44) | SCN9ASCN5AALDH1A1NPSR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101443336-B | Cyclopropyl fused indolobenzazepine HVC ns5b inhibitors | BRISTOL MYERS SQUIBB CO | 2012-07-04 | — | — | CN | disclosed |
| EP-2401280-A1 | Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors | Bristol-Myers Squibb Company (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010099159-A1 | CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-09-02 | — | — | WO | disclosed |