Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 11/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 7/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CD38 | P28907 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19610596 | 0.84 | ACP1 (0.46) | MAP3K8PTGS1PTGS2EGFRERBB2 | |
| SCHEMBL19610564 | 0.68 | CHEK1 (0.40) | MAP3K8PTGS1PTGS2EGFRERBB2 | |
| SCHEMBL19610538 | 0.68 | LMNA (0.37) | EGFRERBB2ACP1SRC | |
| SCHEMBL19610605 | 0.68 | KMT2A (0.41) | PTGS1PTGS2 | |
| SCHEMBL19610541 | 0.67 | LMNA (0.43) | PTGS1PTGS2EGFRERBB2ACP1 | |
| SCHEMBL4775748 | 0.67 | MAPKAPK2 (0.45) | PTGS1PTGS2EGFRACP1SRC | |
| SCHEMBL4776121 | 0.67 | KCNQ3 (0.39) | PTGS2EGFRERBB2MAPKAPK2CD38 | |
| SCHEMBL24539148 | 0.65 | SYK (0.39) | MAP3K8EGFRERBB2IKBKBMMP3 | |
| SCHEMBL4960680 | 0.65 | MAP3K8 (0.67) | MAP3K8EGFRERBB2IKBKBMMP3 | |
| SCHEMBL6071332 | 0.65 | ACP1 (0.63) | EGFRACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198756-A1 | QUINOLINE COMPOUNDS FOR INCREASING INSULINE RELEASE | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-11-23 | — | — | WO | claimed |
| EP-3246028-A1 | QUINOLINE COMPOUNDS FOR INCREASING INSULINE RELEASE | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-11-22 | — | — | EP | claimed |
| WO-2017198756-A1 | QUINOLINE COMPOUNDS FOR INCREASING INSULINE RELEASE | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-11-23 | — | — | WO | disclosed |
| EP-3246028-A1 | QUINOLINE COMPOUNDS FOR INCREASING INSULINE RELEASE | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-11-22 | — | — | EP | disclosed |