Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10723960 | 0.89 | HPGD (0.68) | L3MBTL1TSHRHPGDPOLBMEN1 | |
| SCHEMBL19611154 | 0.84 | HPGD (0.66) | TSHRHPGDPOLBMEN1KMT2A | |
| SCHEMBL4260025 | 0.83 | HPGD (0.60) | L3MBTL3L3MBTL1TSHRHPGDPOLB | |
| SCHEMBL14258634 | 0.82 | HPGD (0.59) | TSHRHPGDPOLBMEN1KMT2A | |
| SCHEMBL18193200 | 0.82 | EPHX2 (0.60) | TSHRHPGDPOLBMEN1KMT2A | |
| SCHEMBL3226822 | 0.81 | HPGD (0.59) | L3MBTL1TSHRHPGDPOLBMEN1 | |
| SCHEMBL8360507 | 0.80 | HPGD (0.73) | L3MBTL1TSHRHPGDPOLBMEN1 | |
| SCHEMBL7363942 | 0.80 | HPGD (0.65) | L3MBTL1TSHRHPGDPOLBMEN1 | |
| SCHEMBL13247636 | 0.79 | PLOD2 (0.60) | HPGDHDAC8HDAC6MEN1KMT2A | |
| SCHEMBL2378760 | 0.78 | KDM1A (0.57) | L3MBTL1TSHRHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | claimed |