Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 20/20 | 1.00 |
| ▸ | MTNR1B | P49286 | 20/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | APEX1 | P27695 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29546622 | 1.00 | MTNR1A (1.00) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| Dimethylamine SCHEMBL3248090 | 0.80 | MTNR1A (0.67) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL3247827 | 0.78 | MTNR1A (0.67) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4437298 | 0.74 | MTNR1A (0.72) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4430575 | 0.74 | MTNR1A (0.72) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL5361550 | 0.70 | MTNR1A (0.67) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL6193835 | 0.69 | MTNR1A (0.66) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL5367094 | 0.69 | MTNR1A (0.55) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL5369933 | 0.68 | MTNR1A (0.54) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL6944686 | 0.68 | MTNR1A (0.57) | MTNR1AMTNR1BKDM4ETSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10555919-B2 | Melatonin in autoimmune disease | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2020-02-11 | — | — | US | disclosed |
| US-20170333371-A1 | MELATONIN IN AUTOIMMUNE DISEASE | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2017-11-23 | — | — | US | disclosed |