Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM6B | O15054 | 3/20 | 0.47 |
| ▸ | KDM5C | P41229 | 3/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.47 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19616912 | 1.00 | KDM4E (0.50) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL19632186 | 0.83 | KDM5C (0.57) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL19615775 | 0.83 | KDM4E (0.51) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL19632101 | 0.83 | KDM5C (0.57) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL19615938 | 0.79 | KDM4E (0.56) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL19615962 | 0.78 | KDM4E (0.52) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL70350 | 0.77 | KDM4E (0.62) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL30065796 | 0.77 | KDM4E (0.62) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL20963391 | 0.77 | KDM4E (0.55) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL30745058 | 0.77 | KDM4E (0.55) | KDM4EALOX15L3MBTL1KDM6BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |