SCHEMBL70350

SCHEMBL70350

COC(=O)c1ccnc(C(=O)OC)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.62
KDM6B O15054 2/20 0.62
KDM5C P41229 2/20 0.62
KDM4C Q9H3R0 2/20 0.62
KDM2A Q9Y2K7 2/20 0.62
KDM3A Q9Y4C1 2/20 0.62
ALOX15 P16050 3/20 0.57
L3MBTL1 Q9Y468 2/20 0.57
MAPK1 P28482 2/20 0.55
JMJD6 Q6NYC1 1/20 0.54
ALDH1A1 P00352 4/20 0.51
MAPT P10636 3/20 0.50
HTT P42858 2/20 0.50
KDM5B Q9UGL1 2/20 0.50
TET3 O43151 1/20 0.50
KDM4A O75164 1/20 0.50
BBOX1 O75936 1/20 0.50
KDM5A P29375 1/20 0.50
ASPH Q12797 1/20 0.50
KDM4D Q6B0I6 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30065796 1.00 KDM4E (0.62) KDM4EKDM6BKDM5CKDM4CKDM2A
SCHEMBL30745026 0.89 KDM4E (0.68) KDM4EKDM6BKDM5CKDM4CKDM2A
SCHEMBL30779113 0.89 KDM4E (0.68) KDM4EKDM6BKDM5CKDM4CKDM2A
SCHEMBL1759313 0.89 KDM4E (0.58) KDM4EKDM6BKDM5CKDM4CKDM2A
SCHEMBL30378954 0.89 KDM4E (0.58) KDM4EKDM6BKDM5CKDM4CKDM2A
SCHEMBL4939178 0.89 KDM4E (0.50) KDM4EKDM6BKDM5CKDM4CKDM2A
SCHEMBL2716237 0.89 KDM4E (0.68) KDM4EKDM6BKDM5CKDM4CKDM2A
SCHEMBL475565 0.89 KDM4E (0.68) KDM4EKDM6BKDM5CKDM4CKDM2A
SCHEMBL30236802 0.89 KDM4E (0.50) KDM4EKDM6BKDM5CKDM4CKDM2A
SCHEMBL1759324 0.87 KDM4E (0.57) KDM4EKDM6BKDM5CKDM4CKDM2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3654929-B1 AQUEOUS COSMETIC COMPOSITION COMPRISING A PYRIDINEDICARBOXYLIC ACID DERIVATIVE AND A HYDROXYSTILBENE OREAL (FR) 2024-05-29 EP claimed
CN-115322350-A Degradable bio-based polyester and preparation method and application thereof 苏州瀚海新材料有限公司 2022-11-11 CN claimed
EP-3654929-A1 AQUEOUS COSMETIC COMPOSITION COMPRISING A PYRIDINEDICARBOXYLIC ACID DERIVATIVE AND A HYDROXYSTILBENE L'OREAL (FR) 2020-05-27 EP claimed
EP-3236919-B1 PARTICULAR PYRIDINEDICARBOXYLIC ACID DERIVATIVE/ANTIOXIDANT COMBINATION OREAL (FR) 2019-10-16 EP claimed
EP-2861206-B1 COMPOSITION INCLUDING A PYRIDINE DICARBOXYLIC ACID ESTER AND A BINDING POLYMER, METHOD THEREFOR, AND USE THEREOF FOR TREATING HAIR OREAL (FR) 2019-06-12 EP claimed
WO-2019016153-A1 AQUEOUS COSMETIC COMPOSITION COMPRISING A PYRIDINEDICARBOXYLIC ACID DERIVATIVE AND A HYDROXYSTILBENE L'OREAL (FR) 2019-01-24 WO claimed
EP-3386476-A1 COMPOSITION COMPRISING A POLYMER CONTAINING A SULFONIC MONOMER AND A PYRIDINEDICARBOXYLIC ACID DERIVATIVE, AND COSMETIC TREATMENT METHOD L'Oréal (FR) 2018-10-17 EP claimed
US-20180148752-A1 PROCESS FOR THE PREPARATION OF 2,4- OR 2,5-PYRIDINEDICARBOXYLIC ACID AND COPOLYMERS DERIVED THEREFROM BIOME BIOPLASTICS LIMITED (GB) 2018-05-31 US claimed
EP-3307901-A1 PROCESS FOR THE PREPARATION OF 2,4- OR 2,5-PYRIDINEDICARBOXYLIC ACID AND COPOLYMERS DERIVED THEREFROM Biome Bioplastics Limited (GB) 2018-04-18 EP claimed
US-20180000712-A1 PARTICULAR PYRIDINEDICARBOXYLIC ACID DERIVATIVE/ANTIOXIDANT COMBINATION L'OREAL (FR) 2018-01-04 US claimed
CN-107106452-A Specific pyridinedicarboxylicacid acid derivatives/antioxidant combination 欧莱雅 2017-08-29 CN claimed
WO-2017097849-A1 COMPOSITION COMPRISING A POLYMER CONTAINING A SULFONIC MONOMER AND A PYRIDINEDICARBOXYLIC ACID DERIVATIVE, AND COSMETIC TREATMENT METHOD L'OREAL (FR) 2017-06-15 WO claimed
WO-2016202875-A1 PROCESS FOR THE PREPARATION OF 2,4- OR 2,5-PYRIDINEDICARBOXYLIC ACID AND COPOLYMERS DERIVED THEREFROM BIOME BIOPLASTICS LIMITED (GB) 2016-12-22 WO claimed
WO-2016102489-A1 PARTICULAR PYRIDINEDICARBOXYLIC ACID DERIVATIVE/ANTIOXIDANT COMBINATION L'OREAL (FR) 2016-06-30 WO claimed
US-9107847-B2 Administration of pyridinedicarboxylic acid compounds for stimulating or inducing the growth of human keratinous fibers and/or arresting their loss SOCIETE L'OREAL S.A. (FR) 2015-08-18 US claimed
EP-1352629-B1 Use of a pyridine-dicarboxylic acid derivative or a salt thereof to stimulate or induce keratinic fiber growth and/or to prevent its loss OREAL (FR) 2011-06-22 EP claimed
US-20030223945-A1 Administration of pyridinedicarboxylic acid compounds for stimulating or inducing the growth of human keratinous fibers and/or arresting their loss SOCIETE L'OREAL S.A. (FR) 2003-12-04 US claimed
US-5939568-A Accelerated catalysis of olefinic epoxidations THE SCRIPPS RESEARCH INSTITUTE (US) 1999-08-17 US claimed
WO-1998033786-A9 ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS 1998-12-30 WO claimed
WO-1998033786-A1 ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS THE SCRIPPS RESEARCH INSTITUTE (US) 1998-08-06 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180000712-A1 PARTICULAR PYRIDINEDICARBOXYLIC ACID DERIVATIVE/ANTIOXIDANT COMBINATION GPX4, PRDX3, DPYD KDM4E 1900/4885KDM6B 1323/4885KDM5C 1306/4885
US-20180148752-A1 PROCESS FOR THE PREPARATION OF 2,4- OR 2,5-PYRIDINEDICARBOXYLIC ACID AND COPOLYMERS DERIVED THEREFROM HPD, PCCA, MVD KDM4E 657/4885KDM6B 484/4885KDM5C 536/4885
US-20030223945-A1 Administration of pyridinedicarboxylic acid compounds for stimulating or inducing the growth of human keratinous fibers and/or arresting their loss KRT18, AKR1C3, MC1R KDM4E 1534/4885KDM6B 895/4885KDM5C 869/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.