Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31398419 | 1.00 | SLC2A1 (0.38) | SLC2A1L3MBTL1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL3469412 | 0.85 | MAPT (0.47) | MAPTSMN1; SMN2RAB9AHPGDCTSD | |
| SCHEMBL7709361 | 0.83 | MAPT (0.37) | SLC2A1L3MBTL1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL15285233 | 0.79 | MAPT (0.47) | L3MBTL1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6940112 | 0.76 | TSHR (0.42) | SLC2A1MAPTABCC9ABCC8KCNJ11 | |
| SCHEMBL7599032 | 0.76 | DNMT1 (0.39) | SLC2A1MAPTSMN1; SMN2RAB9AABCC9 | |
| SCHEMBL19617287 | 0.76 | TDP1 (0.35) | L3MBTL1SMN1; SMN2GAATDP1LMNA | |
| SCHEMBL30560670 | 0.76 | ELANE (0.43) | MAPTSMN1; SMN2NPC1RAB9AGAA | |
| Biphenyl SCHEMBL3921593 | 0.76 | ACLY (0.44) | SLC2A1MAPTSMN1; SMN2TDP1HPGD | |
| SCHEMBL29625664 | 0.75 | SLC2A1 (0.43) | SLC2A1L3MBTL1MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3908283-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-11-17 | — | — | EP | disclosed |
| EP-3710439-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-09-23 | — | — | EP | disclosed |
| WO-2020146613-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-07-16 | — | — | WO | disclosed |
| EP-3458445-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |