Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | IL1RN | P18510 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29668894 | 1.00 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL31566926 | 0.79 | SCN5A (0.51) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL29967633 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL29967512 | 0.79 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL1621377 | 0.79 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL6026817 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL5470797 | 0.78 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL38662799 | 0.76 | ALDH1A1 (0.65) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL29023892 | 0.76 | KDM4E (0.65) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL16757123 | 0.76 | SCN5A (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458449-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | Xenon Pharmaceuticals Inc. (CA) | 2019-03-27 | — | — | EP | claimed |
| WO-2017201468-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2017-11-23 | — | — | WO | claimed |
| CN-115124459-A | Method for selectively nitrating N- (2-pyridyl) benzene sulfonamide compound | 宁波大学 | 2022-09-30 | — | — | CN | disclosed |
| EP-3458449-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | Xenon Pharmaceuticals Inc. (CA) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017201468-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2017-11-23 | — | — | WO | disclosed |