Sugi Predict

Sugi Predict / Compounds / SCHEMBL19619210

SCHEMBL19619210

SCHEMBL19619210

NCC1OC(OC2C(N)C(OC3C(N)CC(N)C4OC5(CCCCC5)OC34)OC3COC4(CCCCC4)OC32)C(OC(=O)c2ccccc2)C1OC(=O)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38
▸ GJB2 P29033 6/20 0.33
▸ LRAT O95237 1/20 0.33
▸ GJA1 P17302 3/20 0.31
▸ LMNA P02545 1/20 0.30
▸ KDM4E B2RXH2 1/20 0.30
▸ ALOX15 P16050 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19944540 0.93 POLB (0.46) POLBGAAMAPK1NPSR1GJB2
SCHEMBL19944109 0.78 — —
SCHEMBL19619212 0.76 LRAT (0.30) LRAT
SCHEMBL19944063 0.75 — —
SCHEMBL19619250 0.75 LRAT (0.36) LRATLMNAKDM4EALOX15
SCHEMBL19619322 0.74 POLB (0.40) POLBGAAMAPK1NPSR1
SCHEMBL19944204 0.73 ALOX15 (0.53) GAAGJB2LRATGJA1LMNA
SCHEMBL17323462 0.73 PTPN1 (0.36) POLBGAAMAPK1NPSR1
SCHEMBL13873389 0.73 PTPN1 (0.36) POLBGAAMAPK1NPSR1
SCHEMBL17323465 0.73 POLB (0.42) POLBGAAMAPK1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9821001-B2 Aminoglycosides and uses thereof in the treatment of genetic disorders TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2017-11-21 — — US disclosed
Send feedback