Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRAT | O95237 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19619212 | 0.90 | LRAT (0.30) | LRAT | |
| SCHEMBL19944063 | 0.85 | — | — | |
| SCHEMBL19944109 | 0.85 | — | — | |
| SCHEMBL19944104 | 0.80 | — | — | |
| SCHEMBL19619210 | 0.75 | POLB (0.38) | LRATLMNAKDM4EALOX15 | |
| SCHEMBL17323725 | 0.69 | — | — | |
| SCHEMBL13890139 | 0.69 | — | — | |
| SCHEMBL17323421 | 0.69 | — | — | |
| SCHEMBL19619249 | 0.69 | — | — | |
| SCHEMBL13873332 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007783-B1 | NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS | TECHNION RES & DEV FOUNDATION (IL) | 2018-07-11 | — | — | EP | disclosed |
| US-9821001-B2 | Aminoglycosides and uses thereof in the treatment of genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2017-11-21 | — | — | US | disclosed |