Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
| ▸ | MLYCD | O95822 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18570673 | 0.89 | TRPV4 (0.39) | TRPV4CHRNA7HSD11B1PTPN5MLYCD | |
| SCHEMBL17775927 | 0.86 | TRPV4 (0.36) | TRPV4CHRNA7HSD11B1PDE2ANR1I2 | |
| SCHEMBL17775982 | 0.86 | TRPV4 (0.36) | TRPV4CHRNA7HSD11B1PDE2ANR1I2 | |
| SCHEMBL21076643 | 0.85 | TRPV4 (0.37) | TRPV4CHRNA7HSD11B1 | |
| SCHEMBL2609310 | 0.84 | TRPV4 (0.52) | TRPV4CHRNA7HSD11B1PDE2AP2RX7 | |
| SCHEMBL26326434 | 0.83 | CHRNA7 (0.35) | TRPV4CHRNA7 | |
| SCHEMBL20390072 | 0.83 | CHRNA7 (0.35) | TRPV4CHRNA7HSD11B1PDE2ANR1I2 | |
| SCHEMBL20390073 | 0.83 | CHRNA7 (0.35) | TRPV4CHRNA7HSD11B1PDE2ANR1I2 | |
| SCHEMBL1694606 | 0.82 | CHRNA7 (0.38) | TRPV4CHRNA7HSD11B1NR1I2CYP2C9 | |
| SCHEMBL20392645 | 0.81 | CHRNA7 (0.35) | TRPV4CHRNA7HSD11B1PDE2APTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9822130-B2 | Triazolo-pyrazinyl derivatives useful as soluble guanylate cyclase activators | MERCK SHARP & DOHME CORP. (US) | 2017-11-21 | — | — | US | disclosed |