Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19619488 | 0.85 | TRPV4 (0.39) | TRPV4CHRNA7HSD11B1 | |
| SCHEMBL18570673 | 0.85 | TRPV4 (0.39) | TRPV4CHRNA7HSD11B1 | |
| SCHEMBL26326434 | 0.84 | CHRNA7 (0.35) | TRPV4CHRNA7 | |
| SCHEMBL2609310 | 0.81 | TRPV4 (0.52) | TRPV4CHRNA7HSD11B1 | |
| SCHEMBL17775927 | 0.79 | TRPV4 (0.36) | TRPV4CHRNA7HSD11B1 | |
| SCHEMBL17775982 | 0.79 | TRPV4 (0.36) | TRPV4CHRNA7HSD11B1 | |
| SCHEMBL12337201 | 0.78 | CHRNA7 (0.35) | TRPV4CHRNA7HSD11B1 | |
| SCHEMBL20392645 | 0.78 | CHRNA7 (0.35) | TRPV4CHRNA7HSD11B1 | |
| SCHEMBL20392646 | 0.78 | CHRNA7 (0.35) | TRPV4CHRNA7HSD11B1 | |
| SCHEMBL20390072 | 0.76 | CHRNA7 (0.35) | TRPV4CHRNA7HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190167681-A1 | SULFONYL PYRIDYL TRP INHIBITORS | GENENTECH, INC. (US) | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190167681-A1 | SULFONYL PYRIDYL TRP INHIBITORS | TRPA1, TRPV1, TRPV5 | TRPV4 6/4885CHRNA7 2361/4885HSD11B1 4251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.