Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19620589 | 0.84 | ADK (0.39) | KDM4EPOLBMAPTSLC6A4MAOB | |
| SCHEMBL19620603 | 0.83 | POLB (0.50) | KDM4EPOLBMAPTRAB9ASCN9A | |
| SCHEMBL19620559 | 0.81 | ALDH1A1 (0.41) | KDM4EPOLBMAPTMAOBRAB9A | |
| SCHEMBL20367966 | 0.80 | TOP2A (0.35) | TOP2AKDM4EPOLBMAPTCFTR | |
| SCHEMBL15627553 | 0.80 | MAPT (0.37) | TOP2AKDM4EPOLBMAPTCFTR | |
| SCHEMBL19620533 | 0.80 | MAPT (0.42) | KDM4EPOLBMAPTRAB9ACYP2C9 | |
| SCHEMBL19620689 | 0.79 | KDM4E (0.38) | KDM4EPOLBMAPTRAB9A | |
| SCHEMBL19620654 | 0.79 | KDM4E (0.38) | KDM4EPOLBMAPT | |
| SCHEMBL19620650 | 0.78 | CYP19A1 (0.42) | KDM4EPOLBMAPTRAB9A | |
| SCHEMBL19620675 | 0.78 | MAPT (0.42) | KDM4EPOLBMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345596-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2021-01-20 | — | — | EP | disclosed |
| EP-2897607-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2017-11-22 | — | — | EP | disclosed |