Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 2/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19620568 | 0.89 | MDM2 (0.36) | MDM2MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL20367974 | 0.88 | MAPT (0.41) | MDM2MAPTMAPK1L3MBTL1KDM4E | |
| SCHEMBL20367968 | 0.88 | KDM4E (0.37) | MAPTMAPK1KDM4EALDH1A1KMT2A | |
| SCHEMBL19620531 | 0.84 | MAPT (0.39) | MDM2TP53RXFP1MAPTMAPK1 | |
| SCHEMBL15627602 | 0.83 | MDM2 (0.37) | MDM2TP53MAPTKDM4EALDH1A1 | |
| SCHEMBL19620664 | 0.83 | MEN1 (0.39) | MAPTL3MBTL1KDM4EALDH1A1LMNA | |
| SCHEMBL19620643 | 0.82 | RAB9A (0.36) | MAPTKDM4EALDH1A1KMT2ACCR2 | |
| SCHEMBL20367775 | 0.82 | KDM4E (0.33) | MDM2MAPTKDM4E | |
| SCHEMBL19620830 | 0.80 | SIRT2 (0.30) | ALDH1A1 | |
| SCHEMBL19620615 | 0.80 | P2RX3 (0.34) | MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345596-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2021-01-20 | — | — | EP | disclosed |