SCHEMBL19620552

SCHEMBL19620552

NC1=C(OSCc2ccccc2)C(=O)C(c2cccc3ccccc23)O1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 8/20 0.39
ADK P55263 4/20 0.39
KDM4E B2RXH2 4/20 0.35
ALDH1A1 P00352 2/20 0.35
MAPK1 P28482 2/20 0.35
LMNA P02545 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C19 P33261 1/20 0.35
CYP2C9 P11712 1/20 0.33
MAPT P10636 3/20 0.32
TDP2 O95551 1/20 0.32
HPGD P15428 1/20 0.32
ALOX12 P18054 1/20 0.32
CASP3 P42574 1/20 0.32
HTT P42858 1/20 0.32
GALK1 P51570 1/20 0.32
BLM P54132 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
SENP8 Q96LD8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19620528 0.83 DPP4 (0.36) ADKKDM4ECYP1A2CYP3A4CYP2C19
SCHEMBL19620625 0.83 CYP1A2 (0.34) KDM4EALDH1A1MAPK1CYP1A2CYP3A4
SCHEMBL19620526 0.83 HTR2C (0.33) KDM4ECYP1A2CYP3A4CYP2C19MAPT
SCHEMBL19620512 0.83 HTR2A (0.33) ADKKDM4ECYP1A2CYP3A4CYP2C19
SCHEMBL19620504 0.82 TP53 (0.43) KDM4EALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL19620571 0.81 HTR2C (0.35) KDM4EALDH1A1CYP1A2CYP3A4CYP2C19
SCHEMBL19620562 0.81 HSD11B1 (0.39) KDM4EALDH1A1LMNAMAPTHTT
SCHEMBL19620603 0.81 POLB (0.50) ADKKDM4EALDH1A1MAPK1LMNA
SCHEMBL19620537 0.81 CYP1A2 (0.32) ADKKDM4ELMNACYP1A2CYP3A4
SCHEMBL19620556 0.81 CYP1A2 (0.32) KDM4EALDH1A1CYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3345596-B1 INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER RHODE ISLAND HOSPITAL (US) 2021-01-20 EP disclosed
EP-3345596-A2 INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER RHODE ISLAND HOSPITAL (US) 2018-07-11 EP disclosed
EP-2897607-B1 INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER RHODE ISLAND HOSPITAL (US) 2017-11-22 EP disclosed