Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | PNP | P00491 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20367974 | 0.84 | MAPT (0.41) | RAB9AKDM4EPOLBMAPTMEN1 | |
| SCHEMBL20367968 | 0.84 | KDM4E (0.37) | RAB9ANPC1KDM4EPOLBMAPT | |
| SCHEMBL19620568 | 0.83 | MDM2 (0.36) | RAB9AKDM4EPOLBMAPTMEN1 | |
| SCHEMBL20367757 | 0.82 | MAPT (0.36) | RAB9AKDM4EPOLBMAPTMEN1 | |
| SCHEMBL22902015 | 0.82 | PTAFR (0.37) | KDM4EMAPTKMT2AALDH1A1CCR2 | |
| SCHEMBL19620573 | 0.80 | RAB9A (0.36) | RAB9ANPC1KDM4EPOLBMAPT | |
| SCHEMBL20367963 | 0.80 | MAPT (0.35) | RAB9AKDM4EPOLBMAPTSMN1; SMN2 | |
| SCHEMBL19620627 | 0.80 | KDM4E (0.38) | RAB9AKDM4EPOLBMAPTSMN1; SMN2 | |
| SCHEMBL16931689 | 0.80 | RAB9A (0.35) | RAB9ANPC1KDM4EPOLBMAPT | |
| SCHEMBL15627602 | 0.79 | MDM2 (0.37) | RAB9AKDM4EPOLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345596-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2021-01-20 | — | — | EP | disclosed |
| EP-2897607-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2017-11-22 | — | — | EP | disclosed |