Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20367968 | 0.94 | KDM4E (0.37) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL20367974 | 0.90 | MAPT (0.41) | MEN1KMT2AALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL15627602 | 0.89 | MDM2 (0.37) | ALDH1A1RAB9AKDM4EPOLBMAPT | |
| SCHEMBL19620568 | 0.87 | MDM2 (0.36) | MEN1KMT2AALDH1A1RAB9AKDM4E | |
| SCHEMBL19620615 | 0.86 | P2RX3 (0.34) | KDM4EPOLBMAPTLMNACNR2 | |
| SCHEMBL19620627 | 0.83 | KDM4E (0.38) | MEN1KMT2AALDH1A1RAB9AKDM4E | |
| SCHEMBL20367775 | 0.83 | KDM4E (0.33) | RAB9AKDM4EPOLBMAPT | |
| SCHEMBL22902015 | 0.83 | PTAFR (0.37) | KMT2AALDH1A1L3MBTL1KDM4EMAPT | |
| SCHEMBL20367757 | 0.81 | MAPT (0.36) | MEN1KMT2AALDH1A1RAB9AKDM4E | |
| SCHEMBL19620621 | 0.81 | MAPT (0.49) | KMT2AALDH1A1RAB9AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897607-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2017-11-22 | — | — | EP | disclosed |