Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19620879 | 0.76 | EZH2 (0.35) | — | |
| SCHEMBL19620960 | 0.71 | EZH2 (0.33) | — | |
| SCHEMBL19620983 | 0.69 | SMN1; SMN2 (0.35) | LMNA | |
| SCHEMBL16115897 | 0.67 | NR4A2 (0.51) | LMNACNR1CYP19A1 | |
| SCHEMBL19621046 | 0.67 | — | — | |
| SCHEMBL16116137 | 0.61 | NR4A2 (0.43) | LMNACNR2CNR1 | |
| SCHEMBL19620958 | 0.59 | PSMB11 (0.31) | — | |
| SCHEMBL19620938 | 0.58 | EZH2 (0.33) | — | |
| SCHEMBL31363868 | 0.58 | NR4A2 (0.41) | LMNA | |
| SCHEMBL31363930 | 0.56 | ASH1L (0.37) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |