Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14717434 | 0.76 | KDM4E (0.48) | SMN1; SMN2GAAACACBALDH1A1KDM4E | |
| SCHEMBL14727056 | 0.73 | EZH2 (0.58) | — | |
| SCHEMBL19620960 | 0.69 | EZH2 (0.33) | — | |
| SCHEMBL19620781 | 0.69 | LMNA (0.32) | LMNA | |
| SCHEMBL14717102 | 0.68 | KDM4E (0.47) | GAAALDH1A1KDM4EKMT2A | |
| SCHEMBL14717869 | 0.67 | PRKAB2 (0.46) | SMN1; SMN2GAAALDH1A1KDM4EMAPT | |
| SCHEMBL17956112 | 0.63 | EZH2 (0.52) | — | |
| SCHEMBL21666232 | 0.61 | SMN1; SMN2 (0.53) | SMN1; SMN2GAAALDH1A1KDM4ENPC1 | |
| SCHEMBL863522 | 0.59 | SMN1; SMN2 (0.81) | SMN1; SMN2GAAALDH1A1KDM4ETHRB | |
| SCHEMBL11204217 | 0.59 | THRB (0.79) | SMN1; SMN2GAAALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |