Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.51 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594958 | 0.81 | EZH2 (0.68) | EZH2EZH1 | |
| SCHEMBL12180172 | 0.81 | EZH2 (0.68) | EZH2EZH1 | |
| SCHEMBL14727027 | 0.81 | EZH2 (0.68) | EZH2EZH1 | |
| SCHEMBL19620789 | 0.79 | EZH2 (0.50) | EZH2 | |
| SCHEMBL19509001 | 0.74 | EZH2 (0.59) | EZH2 | |
| SCHEMBL19620931 | 0.73 | EZH2 (0.41) | EZH2EZH1 | |
| SCHEMBL19620907 | 0.69 | EZH2 (0.47) | EZH2 | |
| SCHEMBL19620910 | 0.69 | EZH2 (0.64) | EZH2EZH1 | |
| SCHEMBL19570165 | 0.69 | EZH2 (0.67) | EZH2EZH1 | |
| SCHEMBL19620821 | 0.69 | EED (0.59) | EZH2EZH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |