Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19622337 | 0.87 | LMNA (0.50) | LMNAMAPK1PDE4BOPRM1OPRD1 | |
| SCHEMBL619879 | 0.79 | LMNA (0.61) | LMNAMAPK1OPRM1OPRD1OPRK1 | |
| SCHEMBL12993276 | 0.78 | LMNA (0.48) | LMNAMAPK1OPRM1OPRD1OPRK1 | |
| SCHEMBL11326977 | 0.77 | MAPT (0.57) | LMNAMAPK1KDM4EL3MBTL1MAPT | |
| SCHEMBL23474086 | 0.77 | LMNA (0.52) | LMNAMAPK1PDE4BKDM4EL3MBTL1 | |
| SCHEMBL21656974 | 0.76 | LMNA (0.60) | LMNAMAPK1OPRM1OPRD1OPRK1 | |
| SCHEMBL21656526 | 0.75 | LMNA (0.63) | LMNAMAPK1KDM4EL3MBTL1TSHR | |
| SCHEMBL19808813 | 0.75 | LMNA (0.47) | LMNAMAPK1KDM4EL3MBTL1MAPT | |
| SCHEMBL30879440 | 0.75 | LMNA (0.62) | LMNAOPRM1OPRD1OPRK1KDM4E | |
| SCHEMBL4596324 | 0.74 | LMNA (0.52) | LMNAMAPK1PDE4BKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246034-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | Anacor Pharmaceuticals, Inc. (US) | 2017-11-22 | — | — | EP | disclosed |