Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 3/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.36 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.34 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16339537 | 0.86 | IKBKE (0.41) | RAF1BRAFIRAK4FSCN1IKBKE | |
| SCHEMBL16340026 | 0.85 | IRAK4 (0.38) | RAF1BRAFIRAK4FSCN1IKBKE | |
| SCHEMBL16339445 | 0.82 | LCK (0.41) | IRAK4FSCN1IKBKETBK1HTT | |
| SCHEMBL16339353 | 0.82 | IKBKE (0.39) | RAF1BRAFIRAK4FSCN1IKBKE | |
| SCHEMBL16339859 | 0.80 | LCK (0.39) | IRAK4FSCN1IKBKETBK1HTT | |
| SCHEMBL16339453 | 0.79 | IRAK4 (0.39) | RAF1BRAFIRAK4IKBKETBK1 | |
| SCHEMBL24033086 | 0.79 | HDAC3 (0.52) | MAPK7 | |
| SCHEMBL16339631 | 0.79 | HDAC2 (0.51) | HPGDSMAPK7 | |
| SCHEMBL16339258 | 0.79 | HDAC2 (0.37) | RAF1BRAFIRAK4FSCN1IKBKE | |
| Hydrochloric Acid SCHEMBL17765374 | 0.78 | HDAC2 (0.50) | HPGDSMAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013345-B1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | HOFFMANN LA ROCHE (CH) | 2017-11-22 | — | — | EP | disclosed |