Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP4 | P49662 | 1/20 | 0.40 |
| ▸ | CASP5 | P51878 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698856 | 0.96 | PIK3CA (0.47) | PIK3CAL3MBTL1LMNAHPGDIGF1R | |
| SCHEMBL24698171 | 0.82 | ALDH1A1 (0.54) | L3MBTL1LMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL24699477 | 0.80 | ALDH1A1 (0.47) | HPGDIGF1RKDM4EALDH1A1GBA1 | |
| SCHEMBL24697795 | 0.80 | ALDH1A1 (0.40) | PIK3CAL3MBTL1LMNAHPGDIGF1R | |
| SCHEMBL24698400 | 0.80 | PIK3CA (0.49) | PIK3CAL3MBTL1LMNAHPGDKDM4E | |
| SCHEMBL24698533 | 0.79 | GBA1 (0.46) | PIK3CAL3MBTL1LMNAHPGDIGF1R | |
| SCHEMBL24698853 | 0.79 | ALDH1A1 (0.37) | PIK3CALMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL29134876 | 0.79 | GBA1 (0.47) | PIK3CAL3MBTL1LMNAHPGDKDM4E | |
| SCHEMBL24698813 | 0.79 | IGF1R (0.37) | HPGDIGF1RKDM4EALDH1A1GBA1 | |
| SCHEMBL24698057 | 0.78 | PIK3CA (0.44) | PIK3CALMNAHPGDIGF1RKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |