Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14262798 | 0.87 | BACE1 (0.47) | L3MBTL1MAPTCACNA1B | |
| SCHEMBL14262613 | 0.84 | KMT2A (0.43) | RAB9AKMT2AMAPTLMNATSHR | |
| SCHEMBL8243016 | 0.82 | LMNA (0.58) | NPC1RAB9AKMT2AMEN1RAD52 | |
| SCHEMBL1955959 | 0.81 | NPC1 (0.51) | NPC1RAB9AKMT2AMEN1RAD52 | |
| SCHEMBL3234489 | 0.81 | NPC1 (0.51) | NPC1RAB9AKMT2AMEN1RAD52 | |
| SCHEMBL19623580 | 0.81 | RAD52 (0.53) | NPC1RAB9AKMT2AMEN1RAD52 | |
| SCHEMBL1292252 | 0.80 | KMT2A (0.63) | NPC1RAB9AKMT2AMEN1RAD52 | |
| SCHEMBL13481376 | 0.80 | FGFR1 (0.46) | NPC1RAB9AKMT2ARAD52MAPT | |
| SCHEMBL10592001 | 0.80 | HTR7 (0.54) | NPC1RAB9AKMT2AMEN1RAD52 | |
| SCHEMBL2479803 | 0.78 | CA1 (0.66) | NPC1RAB9AKMT2APOLBCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |