Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | CETP | P11597 | 4/20 | 0.53 |
| ▸ | GMNN | O75496 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | BLM | P54132 | 3/20 | 0.53 |
| ▸ | UBE2N | P61088 | 3/20 | 0.53 |
| ▸ | THPO | P40225 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL314278 | 1.00 | SPHK1 (0.53) | SPHK1CYP2D6MAPTCETPGMNN | |
| SCHEMBL8574566 | 1.00 | SPHK1 (0.53) | SPHK1CYP2D6MAPTCETPGMNN | |
| SCHEMBL27454783 | 1.00 | SPHK1 (0.53) | SPHK1CYP2D6MAPTCETPGMNN | |
| SCHEMBL2232599 | 1.00 | SPHK1 (0.53) | SPHK1CYP2D6MAPTCETPGMNN | |
| SCHEMBL1963079 | 1.00 | SPHK1 (0.53) | SPHK1CYP2D6MAPTCETPGMNN | |
| SCHEMBL1101078 | 1.00 | SPHK1 (0.53) | SPHK1CYP2D6MAPTCETPGMNN | |
| SCHEMBL4619981 | 0.95 | ALDH1A1 (0.53) | LMNAKDM4ECYP3A4ALDH1A1ALOX15 | |
| SCHEMBL2710460 | 0.95 | ALDH1A1 (0.53) | LMNAKDM4ECYP3A4ALDH1A1ALOX15 | |
| SCHEMBL3992125 | 0.93 | CNR1 (0.54) | MAPTALDH1A1 | |
| SCHEMBL382168 | 0.93 | CNR1 (0.54) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348866-A1 | OXIDIZED LIPID COMPOUNDS AND USES THEREOF | Vascular Biogenics Ltd. (IL) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010052718-A9 | OXIDIZED LIPID COMPOUNDS AND USES THEREOF | VASCULAR BIOGENICS LTD. (IL) | 2011-06-16 | — | — | WO | disclosed |
| WO-2010052718-A1 | OXIDIZED LIPID COMPOUNDS AND USES THEREOF | VASCULAR BIOGENICS LTD. (IL) | 2010-05-14 | — | — | WO | disclosed |