Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26927642 | 0.91 | PIK3CA (0.33) | PIK3CAPIK3CGCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL19627133 | 0.91 | PIK3CA (0.33) | PIK3CAPIK3CGCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL19627124 | 0.90 | — | — | |
| SCHEMBL19627118 | 0.81 | SLC6A4 (0.40) | PIK3CAPIK3CGCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL19627194 | 0.80 | CYP1A2 (0.32) | PIK3CAPIK3CGCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL19627129 | 0.80 | TSHR (0.32) | — | |
| SCHEMBL19627127 | 0.80 | TSHR (0.32) | — | |
| SCHEMBL17793521 | 0.80 | CYP1A2 (0.33) | PIK3CAPIK3CGCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL19627113 | 0.80 | CYP1A2 (0.33) | PIK3CAPIK3CGCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL19630899 | 0.80 | CYP1A2 (0.33) | PIK3CAPIK3CGCYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840541-B2 | Opioid receptor modulators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-12-12 | — | — | US | disclosed |
| US-20230271976-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-08-31 | — | — | US | disclosed |
| US-20170334923-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334923-A1 | OPIOID RECEPTOR MODULATORS | OPRM1, OPRL1, OPRD1 | PIK3CA 4167/4885PIK3CG 3799/4885CYP1A2 376/4885 |
| US-20230271976-A1 | OPIOID RECEPTOR MODULATORS | OPRM1, OPRL1, OPRD1 | PIK3CA 4394/4885PIK3CG 4119/4885CYP1A2 489/4885 |
| US-11840541-B2 | Opioid receptor modulators | OPRM1, OPRL1, OPRD1 | PIK3CA 4167/4885PIK3CG 3799/4885CYP1A2 376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.