Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | UBE2M | P61081 | 4/20 | 0.31 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11573468 | 1.00 | — | — | |
| SCHEMBL20796436 | 0.92 | KDM4E (0.35) | KDM4ETSHRMCL1MEN1KMT2A | |
| SCHEMBL23769767 | 0.90 | HRH3 (0.35) | KDM4ETSHRMCL1MEN1KMT2A | |
| SCHEMBL13881902 | 0.90 | MC4R (0.36) | KDM4ETSHRMCL1MEN1KMT2A | |
| SCHEMBL8737404 | 0.89 | SLC6A3 (0.38) | — | |
| SCHEMBL28225794 | 0.89 | SLC6A3 (0.38) | — | |
| SCHEMBL302084 | 0.89 | SLC6A3 (0.38) | — | |
| SCHEMBL20072506 | 0.88 | KDM4E (0.33) | KDM4ETSHRMCL1MEN1KMT2A | |
| SCHEMBL19629041 | 0.88 | KDM4E (0.40) | KDM4ETSHRMCL1MEN1KMT2A | |
| Iodide SCHEMBL16197417 | 0.87 | SLC6A3 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026254-A1 | ENGINEERED POLYNUCLEOTIDES FOR TEMPORAL CONTROL OF EXPRESSION | MODERNATX, INC. (US) | 2024-02-01 | — | — | WO | disclosed |
| EP-3394030-B1 | COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF AGENTS | MODERNATX INC (US) | 2021-12-22 | — | — | EP | disclosed |
| WO-2019046809-A1 | METHODS OF MAKING LIPID NANOPARTICLES | MODERNATX, INC. (US) | 2019-03-07 | — | — | WO | disclosed |
| WO-2017201332-A1 | POLYNUCLEOTIDES ENCODING ACYL-COA DEHYDROGENASE, VERY LONG-CHAIN FOR THE TREATMENT OF VERY LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY | MODERNATX, INC. (US) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017201346-A1 | POLYNUCLEOTIDES ENCODING PORPHOBILINOGEN DEAMINASE FOR THE TREATMENT OF ACUTE INTERMITTENT PORPHYRIA | MODERNATX, INC. (US) | 2017-11-23 | — | — | WO | disclosed |