Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992708 | 0.77 | KMT2A (0.56) | NPC1RAB9APKMGAAKDM4E | |
| SCHEMBL28131008 | 0.77 | NPC1 (0.56) | NPC1RAB9APKMGAAKDM4E | |
| SCHEMBL1205198 | 0.76 | SMN1; SMN2 (0.51) | NPC1RAB9AGAAKDM4ESMN1; SMN2 | |
| SCHEMBL16261005 | 0.76 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2KMT2AADORA3 | |
| SCHEMBL17266541 | 0.74 | NPC1 (0.66) | NPC1RAB9APKMGAAKDM4E | |
| SCHEMBL29655221 | 0.74 | NPC1 (0.66) | NPC1RAB9APKMGAAKDM4E | |
| SCHEMBL11709551 | 0.73 | MAPT (0.53) | NPC1RAB9AGAAKDM4ESMN1; SMN2 | |
| SCHEMBL9089971 | 0.73 | RAB9A (0.63) | NPC1RAB9APKMGAAKDM4E | |
| SCHEMBL1962172 | 0.72 | NPC1 (0.49) | NPC1RAB9APKMKDM4EMEN1 | |
| SCHEMBL850424 | 0.72 | NPC1 (0.59) | NPC1RAB9AKDM4ESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112041319-B | Triazole, imidazole and pyrrole fused piperazine derivatives and their use as mGlu5Use of modulators of receptors | 利康化学与制药工业有限公司 | 2024-05-14 | — | — | CN | disclosed |
| US-11591337-B2 | Substituted [1,2,4]triazolo[4,3-a]pyrazines as modulators of mGlu5 receptors | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 2023-02-28 | — | — | US | disclosed |
| US-20210047331-A1 | TRIAZOLE, IMIDAZOLE AND PYRROLE CONDENSED PIPERAZINE DERIVATIVES AND THEIR USE AS MODULATORS OF mGlu5 RECEPTORS | RECORDATI IND CHIMICA E FARMACEUTICA S P A (IT) | 2021-02-18 | — | — | US | disclosed |
| EP-3743429-A1 | TRIAZOLE, IMIDAZOLE AND PYRROLE CONDENSED PIPERAZINE DERIVATIVES AND THEIR USE AS MODULATORS OF mGlu5 RECEPTORS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019145214-A1 | TRIAZOLE, IMIDAZOLE AND PYRROLE CONDENSED PIPERAZINE DERIVATIVES AND THEIR USE AS MODULATORS OF mGlu5 RECEPTORS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A (IT) | 2019-08-01 | — | — | WO | disclosed |
| EP-1919892-B1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2013-08-14 | — | — | EP | disclosed |
| US-8481568-B2 | Isoindole-imide compounds and compositions comprising and methods of using the same | CELGENE CORPORATION (US) | 2013-07-09 | — | — | US | disclosed |
| US-20110144158-A1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SEPRACOR INC. | 2011-06-16 | — | — | US | disclosed |
| EP-1919892-A2 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007027527-A2 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2007-03-08 | — | — | WO | disclosed |
| US-20070049618-A1 | Isoindole-imide compounds and compositions comprising and methods of using the same | CELGENE CORPORATION | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210047331-A1 | TRIAZOLE, IMIDAZOLE AND PYRROLE CONDENSED PIPERAZINE DERIVATIVES AND THEIR USE AS MODULATORS OF mGlu5 RECEPTORS | GRM5, GRIK5, GRIN3A | NPC1 2300/4885RAB9A 1808/4885PKM 1236/4885 |
| US-20110144158-A1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SI, CYP3A5, CYP2D6 | NPC1 1007/4885RAB9A 914/4885PKM 1567/4885 |
| US-20070049618-A1 | Isoindole-imide compounds and compositions comprising and methods of using the same | SI, CYP3A5, CYP2D6 | NPC1 1007/4885RAB9A 914/4885PKM 1567/4885 |
| US-11591337-B2 | Substituted [1,2,4]triazolo[4,3-a]pyrazines as modulators of mGlu5 receptors | GRM5, GRIK5, GRM1 | NPC1 2081/4885RAB9A 1986/4885PKM 1270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.