Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 2/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | PLK1 | P53350 | 4/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | IDO1 | P14902 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250247 | 0.89 | HDAC6 (0.80) | HDAC6HDAC8HDAC2HDAC1HPGD | |
| SCHEMBL3673435 | 0.87 | HDAC6 (0.75) | HDAC6HDAC8HDAC2HDAC1CA1 | |
| SCHEMBL3033752 | 0.85 | HDAC6 (0.73) | HDAC6HDAC8HDAC2HDAC1HPGD | |
| SCHEMBL8268108 | 0.83 | HDAC6 (0.71) | HDAC6HDAC8HDAC2HDAC1HPGD | |
| SCHEMBL1665292 | 0.83 | HDAC2 (0.71) | HDAC6HDAC8HDAC2HDAC1HPGD | |
| SCHEMBL14645755 | 0.82 | HDAC6 (0.69) | HDAC6HDAC8HDAC2HDAC1HPGD | |
| SCHEMBL14115137 | 0.82 | HDAC6 (0.70) | HDAC6HDAC8HDAC2HDAC1HPGD | |
| SCHEMBL16198923 | 0.82 | HDAC6 (0.70) | HDAC6HDAC8HDAC2HDAC1HPGD | |
| SCHEMBL14358593 | 0.81 | HDAC6 (0.68) | HDAC6HDAC8HDAC2HDAC1HPGD | |
| SCHEMBL14358587 | 0.81 | HDAC6 (0.68) | HDAC6HDAC8HDAC2HDAC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021013163-A1 | HISTONE DEACETYLASE 6 INHIBITORS AND METHOD FOR TREATING NEUROPATHIC PAIN | TAIPEI MEDICAL UNIVERSITY (CN) | 2021-01-28 | — | — | WO | disclosed |
| WO-2017200966-A1 | HISTONE DEACETYLASE 6 INHIBITORS AND USE THEREOF | DCB-USA LLC (US) | 2017-11-23 | — | — | WO | disclosed |