SCHEMBL3673435

SCHEMBL3673435

O=C(NO)c1ccc(C(=O)NO)cc1

nearest known ligand 0.79

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 9/20 0.75
HDAC1 Q13547 9/20 0.75
HDAC8 Q9BY41 5/20 0.75
HDAC2 Q92769 3/20 0.75
HDAC3 O15379 2/20 0.74
CA1 P00915 2/20 0.74
NCOR2 Q9Y618 2/20 0.74
CA12 O43570 1/20 0.74
IDO1 P14902 1/20 0.74
ALOX15 P16050 1/20 0.74
CA9 Q16790 1/20 0.74
HDAC7 Q8WUI4 1/20 0.74
HSD17B10 Q99714 1/20 0.74
CA2 P00918 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25060935 0.91 HDAC1 (0.75) HDAC6HDAC1HDAC8HDAC2HDAC3
SCHEMBL1151494 0.89 HDAC1 (0.63) HDAC6HDAC1HDAC8HDAC2HDAC3
SCHEMBL8575405 0.89 OGG1 (0.67) HDAC6HDAC1HDAC8HDAC2HDAC3
SCHEMBL3550937 0.89 HDAC6 (0.68) HDAC6HDAC1HDAC8HDAC2HDAC3
SCHEMBL18313990 0.89 HDAC6 (0.62) HDAC6HDAC1HDAC8HDAC2HDAC3
SCHEMBL19631295 0.87 HDAC6 (1.00) HDAC6HDAC1HDAC8HDAC2HDAC3
SCHEMBL297618 0.87 MEN1 (0.61) HDAC6HDAC1HDAC8HDAC2HDAC3
SCHEMBL21694316 0.87 HDAC6 (0.60) HDAC6HDAC1HDAC8HDAC2HDAC3
SCHEMBL12687823 0.87 OGG1 (0.71) HDAC6HDAC1HDAC8HDAC2HDAC3
SCHEMBL2640636 0.87 HDAC6 (0.60) HDAC6HDAC1HDAC8HDAC2HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11981648-B2 Method for the synthesis of 3-R-1,4,2-dioxazol-5-ones TESLA, INC. (US) 2024-05-14 US claimed
CN-114685808-B Hydrogen bond associated pseudo three-dimensional titanium-carbon-based micro complex with one-dimensional pores opened, and preparation method and application thereof 浙江工业大学 2023-02-28 CN claimed
US-20230029852-A1 METHOD FOR THE SYNTHESIS OF 3-R-1,4,2-DIOXAZOL-5-ONES PANASONIC HOLDINGS CORPORATION (JP) 2023-02-02 US claimed
CN-114685808-A Hydrogen bond associated pseudo three-dimensional titanium-carbon-based micro complex with one-dimensional pores opened, and preparation method and application thereof 浙江工业大学 2022-07-01 CN claimed
US-20250084551-A1 CARBON DIOXIDE CONVERSION DEVICE AND CARBON DIOXIDE CONVERSION METHOD Toshiba Energy Systems & Solutions Corporation (JP) 2025-03-13 US disclosed
EP-4520855-A1 CARBON DIOXIDE CONVERSION DEVICE AND CARBON DIOXIDE CONVERSION METHOD Toshiba Energy Systems & Solutions Corporation (JP) 2025-03-12 EP disclosed
WO-2024031002-A1 (2,4-DICHLOROPHENOXY)ACETIC ACID ANALOGS CORTEVA AGRISCIENCE LLC (US) 2024-02-08 WO disclosed
CN-114685808-B Hydrogen bond associated pseudo three-dimensional titanium-carbon-based micro complex with one-dimensional pores opened, and preparation method and application thereof 浙江工业大学 2023-02-28 CN disclosed
CN-114685808-B Hydrogen bond associated pseudo three-dimensional titanium-carbon-based micro complex with one-dimensional pores opened, and preparation method and application thereof 浙江工业大学 2023-02-28 CN disclosed
US-20230056785-A1 GAS-STORING MATERIAL INCLUDING METAL/ORGANIC FRAMEWORK BONDED BY HYDROXAMIC ACID RIKKYO EDUCATIONAL CORPORATION (JP) 2023-02-23 US disclosed
US-20230056785-A1 GAS-STORING MATERIAL INCLUDING METAL/ORGANIC FRAMEWORK BONDED BY HYDROXAMIC ACID RIKKYO EDUCATIONAL CORPORATION (JP) 2023-02-23 US disclosed
EP-4074692-A1 GAS-STORING MATERIAL INCLUDING METAL/ORGANIC FRAMEWORK BONDED BY HYDROXAMIC ACID Rikkyo Educational Corporation (JP) 2022-10-19 EP disclosed
EP-0594577-B1 NOVEL POTENT INDUCERS OF TERMINAL DIFFERENTIATION AND METHOD OF USE THEREOF SLOAN KETTERING INST CANCER (US) 1998-12-30 EP disclosed
US-5840960-A ANTITUMOR SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1998-11-24 US disclosed
US-5608108-A ANTITUMOR AGENTS; LUNG, BLADDER, KIDNEY, BREAST, COLORECTAL SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1997-03-04 US disclosed
EP-0594577-A1 NOVEL POTENT INDUCERS OF TERMINAL DIFFERENTIATION AND METHOD OF USE THEREOF Sloan-Kettering Institute For Cancer Research (US) 1994-05-04 EP disclosed
US-5175191-A Antitumor agents or anticancer agents SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1992-12-29 US disclosed
WO-1991008191-A1 NOVEL POTENT INDUCERS OF TERMINAL DIFFERENTIATION AND METHOD OF USE THEREOF SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1991-06-13 WO disclosed
WO-1991000257-A1 NOVEL POTENT INDUCERS OF TERMINAL DIFFERENTIATION AND METHODS OF USE THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 1991-01-10 WO disclosed
US-3954718-A Process for preparing polymers containing carbamoyl-hydroxamate groups and the resultant polymers STANFORD RESEARCH INSTITUTE (US) 1976-05-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11981648-B2 Method for the synthesis of 3-R-1,4,2-dioxazol-5-ones CYP4X1, DDO, CYP4B1 HDAC6 1947/4885HDAC1 1595/4885HDAC8 2130/4885
US-20230029852-A1 METHOD FOR THE SYNTHESIS OF 3-R-1,4,2-DIOXAZOL-5-ONES CYP4X1, DDO, CYP4B1 HDAC6 1947/4885HDAC1 1595/4885HDAC8 2130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.