Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815212 | 0.86 | POLB (0.36) | POLBMAPK1KDM4ELMNAMEN1 | |
| SCHEMBL3815209 | 0.86 | POLB (0.36) | POLBMAPK1KDM4ELMNAMEN1 | |
| SCHEMBL10203579 | 0.86 | POLB (0.36) | POLBMAPK1KDM4ELMNAMEN1 | |
| SCHEMBL1752084 | 0.85 | ALDH1A1 (0.39) | POLBMAPK1LMNAMEN1KMT2A | |
| SCHEMBL6092422 | 0.80 | SMN1; SMN2 (0.37) | POLBKDM4EMEN1KMT2AGAA | |
| SCHEMBL26704563 | 0.80 | SLC6A4 (0.35) | POLBMAPK1KDM4ELMNAKMT2A | |
| SCHEMBL27634574 | 0.79 | MAPK1 (0.37) | POLBMAPK1KDM4ELMNAMEN1 | |
| SCHEMBL24515538 | 0.79 | ALDH1A1 (0.34) | POLBMAPK1KDM4ELMNAMEN1 | |
| SCHEMBL5180 | 0.79 | MAPK1 (0.55) | POLBMAPK1KDM4ELMNAMEN1 | |
| SCHEMBL5270 | 0.79 | MAPK1 (0.55) | POLBMAPK1KDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3750910-A1 | TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY | VIIV Healthcare UK(No.4) Limited (GB) | 2020-12-16 | — | — | EP | disclosed |
| US-10245275-B2 | Triterpenoids with HIV maturation inhibitory activity | VIIV HEALTHCARE UK (NO. 4) LIMITED (GB) | 2019-04-02 | — | — | US | disclosed |
| US-9969767-B2 | Oxolupene derivatives | VIIV Healthcare UK (No.5) Limited (GB) | 2018-05-15 | — | — | US | disclosed |
| US-20170340650-A1 | TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY | 2017-11-30 | — | — | US | disclosed |
| US-20170334946-A1 | OXOLUPENE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334946-A1 | OXOLUPENE DERIVATIVES | BET1, CYP51A1, PGGT1B | POLB 98/4885MAPK1 3859/4885KDM4E 1645/4885 |
| US-10245275-B2 | Triterpenoids with HIV maturation inhibitory activity | CYP51A1, CYP8B1, LSS | POLB 1857/4885MAPK1 2233/4885KDM4E 2728/4885 |
| US-20170340650-A1 | TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY | CYP51A1, CYP8B1, LSS | POLB 1857/4885MAPK1 2233/4885KDM4E 2728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.