SCHEMBL19615641

SCHEMBL19615641

O=C(O)c1ccnc(/C(COc2ccc(OCc3ccccc3)cc2)=N/O)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G4B P0C869 1/20 0.54
NR4A2 P43354 2/20 0.53
NR4A1 P22736 1/20 0.53
NR4A3 Q92570 1/20 0.53
SRD5A2 P31213 1/20 0.50
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
NR1H4 Q96RI1 1/20 0.46
MRGPRX4 Q96LA9 5/20 0.46
TP53 P04637 2/20 0.46
PKM P14618 2/20 0.46
NFKB1 P19838 2/20 0.46
NFKB2 Q00653 2/20 0.46
RELA Q04206 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
RXRA P19793 1/20 0.46
RXRB P28702 1/20 0.46
RXRG P48443 1/20 0.46
RAB9A P51151 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19615441 0.93 NR4A2 (0.57) PLA2G4BNR4A2NR4A1NR4A3SRD5A2
SCHEMBL19631994 0.90 KDM6B (0.51) PLA2G4BNR4A2PKMKDM5AKDM4C
SCHEMBL19615548 0.90 NR4A2 (0.56) PLA2G4BNR4A2KDM5AKDM4CKDM5B
SCHEMBL19615650 0.90 NR4A2 (0.52) PLA2G4BNR4A2NR4A1NR4A3SRD5A2
SCHEMBL19615967 0.88 MAPT (0.47) MEN1KMT2ASMN1; SMN2RAB9AKDM5A
SCHEMBL19615974 0.88 KDM6B (0.47) SRD5A2PKMSMN1; SMN2RAB9AKDM5A
SCHEMBL19615691 0.87 KDM5A (0.48) PLA2G4BNR4A2NR4A1NR4A3MEN1
SCHEMBL19615520 0.85 NR4A2 (0.61) NR4A2NR4A1NR4A3KMT2AMRGPRX4
SCHEMBL19632083 0.85 PTPN7 (0.51) MEN1KMT2AMRGPRX4NFKB1NFKB2
SCHEMBL19615734 0.84 KDM4C (0.48) PLA2G4BMRGPRX4TP53PKMNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017198785-A1 OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2017-11-23 WO claimed
WO-2017198785-A1 OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2017-11-23 WO disclosed
WO-2017198785-A1 OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2017-11-23 WO disclosed