Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1003179 | 0.83 | PDE4A (0.46) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL21392440 | 0.80 | PDE4A (0.43) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL26925735 | 0.69 | CYP3A4 (0.66) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL10812168 | 0.69 | PDE4A (0.53) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL30013079 | 0.68 | ADORA2A (0.46) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL25457796 | 0.66 | CDK1 (0.36) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9844553 | 0.66 | PDE4A (0.56) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL1003427 | 0.66 | PARN (0.48) | CYP3A4MAPTMEN1KMT2ATLR7 | |
| SCHEMBL27461932 | 0.66 | PDE4A (0.49) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL24995508 | 0.66 | PDE4A (0.45) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017201187-A1 | LIM KINASE INHIBITORS | VIRONGY, LLC (US) | 2017-11-23 | — | — | WO | disclosed |