Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | BAX | Q07812 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12228517 | 0.72 | LTA4H (0.41) | LTA4HTSHRNR1H2BAXTDP1 | |
| SCHEMBL8411617 | 0.70 | PRSS1 (0.40) | LTA4HTSHRCA1CA2NR1H2 | |
| SCHEMBL8483797 | 0.70 | CA4 (0.42) | LTA4HTSHRNR1H2BAXTDP1 | |
| SCHEMBL22920659 | 0.68 | TDP1 (0.47) | LTA4HTSHRTDP1HPGDMAPT | |
| SCHEMBL12782035 | 0.67 | PRSS1 (0.45) | LTA4HTSHRTDP1MAPTKDM4E | |
| SCHEMBL2665439 | 0.66 | LTA4H (0.45) | LTA4HTSHRNR1H2BAXTDP1 | |
| SCHEMBL9748729 | 0.66 | LTA4H (0.45) | LTA4HTSHRNR1H2BAXTDP1 | |
| SCHEMBL9748734 | 0.66 | LTA4H (0.45) | LTA4HTSHRNR1H2BAXTDP1 | |
| SCHEMBL10253371 | 0.65 | MAPT (0.36) | LTA4HTSHRNR1H2BAXTDP1 | |
| SCHEMBL21842904 | 0.65 | TDP1 (0.39) | LTA4HTSHRNR1H2BAXTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9994553-B2 | Process for the purification of the Axl tyrosine receptor kinase inhibitor “R428” | BERGENBIO AS (NO) | 2018-06-12 | — | — | US | disclosed |
| US-9994553-B2 | Process for the purification of the Axl tyrosine receptor kinase inhibitor “R428” | BERGENBIO AS (NO) | 2018-06-12 | — | — | US | disclosed |
| US-20170334884-A1 | PROCESS FOR THE PURIFICATION OF THE AXL TYROSINE RECEPTOR KINASE INHIBITOR \"R428\ | BERGENBIO ASA (NO) | 2017-11-23 | — | — | US | disclosed |
| US-20170334884-A1 | PROCESS FOR THE PURIFICATION OF THE AXL TYROSINE RECEPTOR KINASE INHIBITOR \"R428\ | BERGENBIO ASA (NO) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334884-A1 | PROCESS FOR THE PURIFICATION OF THE AXL TYROSINE RECEPTOR KINASE INHIBITOR \"R428\ | AXL, TYRO3, RET | LTA4H 4679/4885TSHR 121/4885CA1 2209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.