Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19633456 | 0.91 | MAPT (0.51) | MAPTSIRT6LMNARECQLALDH1A1 | |
| SCHEMBL22114735 | 0.82 | LMNA (0.56) | MAPTSIRT6LMNARECQLALDH1A1 | |
| SCHEMBL111292 | 0.81 | LMNA (0.66) | MAPTSIRT6LMNARECQLALDH1A1 | |
| SCHEMBL28253934 | 0.79 | MAPT (0.52) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL979867 | 0.79 | LMNA (0.77) | MAPTSIRT6LMNARECQLALDH1A1 | |
| SCHEMBL19633404 | 0.79 | MAPT (0.53) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL10330200 | 0.78 | SIRT6 (0.78) | MAPTSIRT6LMNARECQLALDH1A1 | |
| SCHEMBL21761929 | 0.78 | LMNA (0.58) | MAPTSIRT6LMNARECQLALDH1A1 | |
| SCHEMBL19633348 | 0.77 | MEN1 (0.58) | MAPTSIRT6LMNARECQLALDH1A1 | |
| SCHEMBL21836042 | 0.76 | LMNA (0.49) | MAPTSIRT6LMNARECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12358898-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2025-07-15 | — | — | US | disclosed |
| US-20240018130-A1 | Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2024-01-18 | — | — | US | disclosed |
| US-20240018130-A1 | Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2024-01-18 | — | — | US | disclosed |
| US-11827625-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. | 2023-11-28 | — | — | US | disclosed |
| US-11827625-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. | 2023-11-28 | — | — | US | disclosed |
| EP-3459952-B1 | PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME AND USE THEREOF IN MEDICINE | ZHEJIANG HISUN PHARM CO LTD (CN) | 2022-01-05 | — | — | EP | disclosed |
| US-20210221797-A1 | Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2021-07-22 | — | — | US | disclosed |
| CN-108884097-B | Pyrimidine derivatives, preparation method thereof and application thereof in medicine | 浙江海正药业股份有限公司 | 2021-05-28 | — | — | CN | disclosed |
| US-11001572-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. | 2021-05-11 | — | — | US | disclosed |
| US-20200207745-A1 | Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2020-07-02 | — | — | US | disclosed |
| US-10654836-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2020-05-19 | — | — | US | disclosed |
| US-20190161476-A1 | Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2019-05-30 | — | — | US | disclosed |
| EP-3459952-A1 | PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME AND USE THEREOF IN MEDICINE | Zhejiang Hisun Pharmaceutical Co., Ltd. (CN) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017198221-A1 | PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME AND USE THEREOF IN MEDICINE | 浙江海正药业股份有限公司 | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200207745-A1 | Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine | FGFR4, FGFR1, FGFR2 | MAPT 2403/4885SIRT6 1752/4885LMNA 4760/4885 |
| US-11827625-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | FGFR4, FGFR1, FGFR2 | MAPT 2403/4885SIRT6 1752/4885LMNA 4760/4885 |
| US-12358898-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | FGFR4, FGFR1, FGFR2 | MAPT 2403/4885SIRT6 1752/4885LMNA 4760/4885 |
| US-10654836-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | FGFR4, FGFR1, FGFR2 | MAPT 2403/4885SIRT6 1752/4885LMNA 4760/4885 |
| US-20240018130-A1 | Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine | FGFR4, FGFR1, FGFR2 | MAPT 2403/4885SIRT6 1752/4885LMNA 4760/4885 |
| US-20190161476-A1 | Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine | FGFR4, FGFR1, FGFR2 | MAPT 2403/4885SIRT6 1752/4885LMNA 4760/4885 |
| US-20210221797-A1 | Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine | FGFR4, FGFR1, FGFR2 | MAPT 2403/4885SIRT6 1752/4885LMNA 4760/4885 |
| US-11001572-B2 | Pyrimidine derivative, method for preparing same and use thereof in medicine | FGFR4, FGFR1, FGFR2 | MAPT 2403/4885SIRT6 1752/4885LMNA 4760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.