Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19634236 | 0.91 | KDM4E (0.35) | TSHRALDH1A1NPSR1KDM4EMEN1 | |
| SCHEMBL19634057 | 0.84 | KDM4E (0.34) | TSHRALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL19634002 | 0.84 | DHFR (0.34) | TSHRALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL21117665 | 0.80 | SCN9A (0.37) | TSHRALDH1A1NPSR1KDM4EMEN1 | |
| SCHEMBL19001230 | 0.79 | KDM4E (0.35) | TSHRALDH1A1NPSR1KDM4EMEN1 | |
| SCHEMBL20256918 | 0.76 | SCN1A (0.51) | TSHRKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22089038 | 0.76 | HTR2A (0.36) | TSHRALDH1A1NPSR1KDM4EMEN1 | |
| SCHEMBL22087758 | 0.76 | POLB (0.35) | TSHRALDH1A1NPSR1KDM4EMEN1 | |
| SCHEMBL26184797 | 0.76 | HTR2A (0.38) | TSHRALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL22088610 | 0.74 | ALDH1A1 (0.35) | TSHRALDH1A1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017201468-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2017-11-23 | — | — | WO | disclosed |