Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GYS1 | P13807 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23471225 | 0.85 | GYS1 (0.53) | GYS1KMT2AMEN1HSD17B1HSD17B2 | |
| SCHEMBL791928 | 0.83 | SMN1; SMN2 (0.49) | KMT2AMEN1HSD17B1HSD17B2CYP4F2 | |
| SCHEMBL1556278 | 0.81 | SMN1; SMN2 (0.47) | KMT2AMEN1HSD17B1HSD17B2CYP4F2 | |
| SCHEMBL23471215 | 0.80 | MEN1 (0.50) | GYS1KMT2AMEN1HSD17B1HSD17B2 | |
| SCHEMBL23471221 | 0.80 | MEN1 (0.50) | GYS1KMT2AMEN1HSD17B1HSD17B2 | |
| SCHEMBL23471001 | 0.80 | KMT2A (0.47) | GYS1KMT2AMEN1HSD17B1HSD17B2 | |
| SCHEMBL23471148 | 0.79 | CYP4F2 (0.55) | GYS1KMT2AMEN1CYP4F2CYP4A11 | |
| SCHEMBL21015933 | 0.78 | KMT2A (0.45) | GYS1KMT2AMEN1HSD17B1HSD17B2 | |
| SCHEMBL19903834 | 0.77 | HPGD (0.58) | GYS1KMT2AMEN1HSD17B1HSD17B2 | |
| SCHEMBL19634278 | 0.77 | MEN1 (0.47) | GYS1KMT2AMEN1HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3831841-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T Global Inc. (US) | 2021-06-09 | — | — | EP | disclosed |
| WO-2017200984-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. (US) | 2017-11-23 | — | — | WO | disclosed |