Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.56 |
| ▸ | ATR | Q13535 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | GYS1 | P13807 | 1/20 | 0.42 |
| ▸ | LOX | P28300 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23471221 | 0.87 | MEN1 (0.50) | LOXL2ATRMEN1KMT2AROCK2 | |
| SCHEMBL23470993 | 0.86 | KMT2A (0.50) | LOXL2ATRMEN1KMT2AROCK2 | |
| SCHEMBL23471114 | 0.85 | LOXL2 (0.51) | LOXL2ATRMEN1KMT2ANAMPT | |
| SCHEMBL18301734 | 0.85 | KMT2A (0.51) | ATRMEN1KMT2AROCK2NAMPT | |
| SCHEMBL23471001 | 0.84 | KMT2A (0.47) | ATRMEN1KMT2AROCK2NAMPT | |
| SCHEMBL17790195 | 0.84 | ROCK2 (0.51) | LOXL2ATRMEN1KMT2AROCK2 | |
| SCHEMBL6346088 | 0.83 | ATR (0.51) | ATRMEN1KMT2AROCK2NAMPT | |
| SCHEMBL21015933 | 0.82 | KMT2A (0.45) | ATRMEN1KMT2AROCK2NAMPT | |
| SCHEMBL12677910 | 0.81 | HPGD (0.54) | ATRMEN1KMT2ANAMPTHSD17B2 | |
| SCHEMBL21015857 | 0.81 | ROCK2 (0.49) | ATRMEN1KMT2AROCK2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3831841-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T Global Inc. (US) | 2021-06-09 | — | — | EP | disclosed |
| WO-2017200984-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. (US) | 2017-11-23 | — | — | WO | disclosed |