SCHEMBL19634702

SCHEMBL19634702

CC(=O)NCc1cccc(C(=O)N(C)C)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.52
HDAC6 Q9UBN7 2/20 0.52
HDAC3 O15379 1/20 0.52
HDAC4 P56524 1/20 0.52
HDAC7 Q8WUI4 1/20 0.52
HDAC2 Q92769 1/20 0.52
HDAC10 Q969S8 1/20 0.52
HDAC11 Q96DB2 1/20 0.52
HDAC8 Q9BY41 1/20 0.52
HDAC9 Q9UKV0 1/20 0.52
HDAC5 Q9UQL6 1/20 0.52
ROCK2 O75116 2/20 0.48
LIPG Q9Y5X9 1/20 0.48
ROCK1 Q13464 1/20 0.48
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
BRD4 O60885 1/20 0.46
MAPK1 P28482 1/20 0.45
NR1H4 Q96RI1 2/20 0.45
MMP13 P45452 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13853839 0.85 NAMPT (0.47) ROCK2LIPGROCK1KMT2AMEN1
SCHEMBL19634729 0.84 HDAC3 (0.47) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL17790190 0.84 KMT2A (0.49) ROCK2LIPGROCK1KMT2AMEN1
SCHEMBL21015876 0.84 NR1H4 (0.48) HDAC1HDAC6ROCK2LIPGROCK1
SCHEMBL8646446 0.83 HDAC1 (0.57) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL3530258 0.82 KMT2A (0.64) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL19634746 0.81 MMP13 (0.49) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL24299182 0.81 CA1 (0.56) HDAC6HDAC2HDAC8ROCK2ROCK1
SCHEMBL1899410 0.81 NPSR1 (0.57) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL2828029 0.81 F10 (0.57) HDAC1HDAC6HDAC3HDAC4HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017200984-A1 NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF S&T GLOBAL INC. (US) 2017-11-23 WO disclosed