Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28656087 | 1.00 | LMNA (0.39) | LMNASMN1; SMN2NPC1NR2F2HTT | |
| SCHEMBL21802200 | 0.90 | MAPT (0.37) | LMNASMN1; SMN2MAPTGAAKDM4E | |
| SCHEMBL21802201 | 0.90 | MAPT (0.37) | LMNASMN1; SMN2MAPTGAAKDM4E | |
| SCHEMBL19615217 | 0.89 | ESRRB (0.45) | LMNASMN1; SMN2NPC1NR2F2HTT | |
| SCHEMBL19635385 | 0.89 | ESRRB (0.45) | LMNASMN1; SMN2NPC1NR2F2HTT | |
| SCHEMBL19634868 | 0.82 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2NPC1NR2F2HTT | |
| SCHEMBL19635389 | 0.82 | ESRRG (0.38) | LMNASMN1; SMN2NPC1NR2F2HTT | |
| SCHEMBL23251241 | 0.82 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2NPC1NR2F2HTT | |
| SCHEMBL19635767 | 0.80 | SMN1; SMN2 (0.45) | LMNASMN1; SMN2NPC1NR2F2HTT | |
| SCHEMBL19635047 | 0.77 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2NPC1NR2F2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |