Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | SORD | Q00796 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19615367 | 0.89 | MEN1 (0.44) | MEN1KMT2AMCL1SORDALDH1A1 | |
| SCHEMBL21802224 | 0.85 | MCL1 (0.45) | MEN1KMT2AMCL1SORDALDH1A1 | |
| SCHEMBL19615270 | 0.78 | MEN1 (0.45) | MEN1KMT2AMCL1ALDH1A1MAPT | |
| SCHEMBL19615199 | 0.78 | MCL1 (0.41) | MEN1KMT2AMCL1ALDH1A1MAPT | |
| SCHEMBL30001005 | 0.78 | MEN1 (0.48) | MEN1KMT2AMCL1SORDALDH1A1 | |
| SCHEMBL21802226 | 0.76 | MCL1 (0.44) | MEN1KMT2AMCL1ALDH1A1MAPT | |
| Acetic Acid SCHEMBL28656086 | 0.76 | MCL1 (0.46) | MEN1KMT2AMCL1SORDALDH1A1 | |
| SCHEMBL20522228 | 0.76 | MCL1 (0.51) | MEN1KMT2AMCL1BCL2 | |
| SCHEMBL28656085 | 0.74 | MCL1 (0.42) | MEN1KMT2AMCL1SORDALDH1A1 | |
| SCHEMBL20521562 | 0.74 | MCL1 (0.47) | MEN1KMT2AMCL1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |