Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 14/20 | 0.51 |
| ▸ | BCL2 | P10415 | 5/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.37 |
| ▸ | PMAIP1 | Q13794 | 1/20 | 0.36 |
| ▸ | BAD | Q92934 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20521727 | 0.95 | MCL1 (0.55) | MCL1BCL2BCL2L1PMAIP1BAD | |
| SCHEMBL20521562 | 0.94 | MCL1 (0.47) | MCL1BCL2BCL2L1MEN1KMT2A | |
| SCHEMBL20521844 | 0.90 | MCL1 (0.50) | MCL1BCL2BCL2L1MEN1KMT2A | |
| SCHEMBL20521731 | 0.85 | MCL1 (0.46) | MCL1BCL2BCL2L1BADMEN1 | |
| SCHEMBL20521751 | 0.85 | MCL1 (0.54) | MCL1BCL2BCL2L1PMAIP1BAD | |
| SCHEMBL20521921 | 0.80 | MCL1 (0.50) | MCL1BCL2BCL2L1PMAIP1MEN1 | |
| SCHEMBL19635340 | 0.76 | MEN1 (0.45) | MCL1BCL2MEN1KMT2A | |
| SCHEMBL20522169 | 0.75 | BCL2 (0.46) | MCL1BCL2BCL2L1PMAIP1BAD | |
| SCHEMBL20521806 | 0.73 | BAD (0.42) | BCL2BCL2L1BAD | |
| SCHEMBL19615367 | 0.73 | MEN1 (0.44) | MCL1BCL2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018178226-A1 | MCL-1 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2018-10-04 | — | — | WO | disclosed |