Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.72 |
| ▸ | JAK2 | O60674 | 12/20 | 0.72 |
| ▸ | JAK1 | P23458 | 7/20 | 0.58 |
| ▸ | TYK2 | P29597 | 4/20 | 0.54 |
| ▸ | BTK | Q06187 | 6/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635668 | 0.87 | JAK3 (0.77) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL19635681 | 0.85 | JAK3 (0.54) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL19635801 | 0.83 | JAK2 (0.71) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL17479775 | 0.80 | BTK (0.74) | JAK3BTKEGFR | |
| SCHEMBL19635795 | 0.79 | JAK3 (0.61) | JAK3JAK2JAK1BTKEGFR | |
| SCHEMBL130641 | 0.76 | PIK3CD (0.60) | JAK3EGFR | |
| SCHEMBL19636023 | 0.76 | JAK2 (0.64) | JAK3JAK2BTKEGFR | |
| SCHEMBL19635797 | 0.76 | JAK2 (0.64) | JAK3JAK2BTKEGFR | |
| SCHEMBL17479836 | 0.74 | BTK (0.72) | BTKEGFR | |
| SCHEMBL17479837 | 0.74 | BTK (0.72) | BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198049-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | 浙江予川医药科技有限公司 | 2017-11-23 | — | — | WO | disclosed |