Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.77 |
| ▸ | JAK2 | O60674 | 17/20 | 0.77 |
| ▸ | JAK1 | P23458 | 11/20 | 0.61 |
| ▸ | TYK2 | P29597 | 7/20 | 0.57 |
| ▸ | BTK | Q06187 | 4/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635666 | 0.87 | JAK3 (0.72) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL19635801 | 0.79 | JAK2 (0.71) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL17479775 | 0.76 | BTK (0.74) | JAK3BTKEGFR | |
| SCHEMBL28888772 | 0.75 | JAK2 (0.64) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL28888774 | 0.75 | JAK2 (0.64) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL19635797 | 0.75 | JAK2 (0.64) | JAK3JAK2BTKEGFR | |
| SCHEMBL19636023 | 0.75 | JAK2 (0.64) | JAK3JAK2BTKEGFR | |
| SCHEMBL19635795 | 0.75 | JAK3 (0.61) | JAK3JAK2JAK1BTKPIK3CD | |
| SCHEMBL19635803 | 0.75 | JAK2 (0.64) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL28399199 | 0.73 | JAK2 (0.65) | JAK3JAK2JAK1BTKPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198049-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | 浙江予川医药科技有限公司 | 2017-11-23 | — | — | WO | disclosed |